The metastatic process: methodological advances and pharmacological challenges.

  title={The metastatic process: methodological advances and pharmacological challenges.},
  author={Antonio Mazzocca and Vinicio Carloni},
  journal={Current medicinal chemistry},
  volume={16 14},
The metastatic spread of cancer is still the major barrier to the treatment of this disease. Understanding the molecular mechanisms underlying the metastatic process is of crucial importance to tune novel therapeutic strategies aimed at contrasting the dissemination of cancer. Metastasis is a sequential multistep process that ultimately leads to the cancer's outgrowth in a different organ from which it had originated. This clinically and experimentally involves the following steps: invasion of… CONTINUE READING
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