The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54.

@article{Kotani2001TheMS,
  title={The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54.},
  author={Masato Kotani and Stephane Brezillon and Ann L. Vandenbogaerde and Sabine Pirotton and Jean Marie Vanderwinden and Emmanuel Le Poul and St{\'e}phane Br{\'e}zillon and Richard Tyldesley and Nathalie Suarez-Huerta and Fabrice Vandeput and C{\'e}dric Blanpain and Serge N. Schiffmann and G. Vassart and Marc Parmentier},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 37},
  pages={
          34631-6
        }
}
Natural peptides displaying agonist activity on the orphan G protein-coupled receptor GPR54 were isolated from human placenta. These 54-, 14,- and 13-amino acid peptides, with a common RF-amide C terminus, derive from the product of KiSS-1, a metastasis suppressor gene for melanoma cells, and were therefore designated kisspeptins. They bound with low nanomolar affinities to rat and human GPR54 expressed in Chinese hamster ovary K1 cells and stimulated PIP(2) hydrolysis, Ca(2+) mobilization… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 557 CITATIONS, ESTIMATED 36% COVERAGE

Kisspeptin modulates fertilization capacity of mouse spermatozoa.

  • Reproduction
  • 2014
VIEW 18 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Potential roles for the kisspeptin/kisspeptin receptor system in implantation and placentation

  • Human reproduction update
  • 2019
VIEW 11 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2001
2019

CITATION STATISTICS

  • 115 Highly Influenced Citations

  • Averaged 25 Citations per year from 2017 through 2019

Similar Papers

Loading similar papers…