The metastasis-associated gene CD24 is regulated by Ral GTPase and is a mediator of cell proliferation and survival in human cancer.

@article{Smith2006TheMG,
  title={The metastasis-associated gene CD24 is regulated by Ral GTPase and is a mediator of cell proliferation and survival in human cancer.},
  author={Steven Christopher Smith and Gary Oxford and Zhong Wu and Matthew D. Nitz and Mark A Conaway and Henry F. Frierson and Garret M. Hampton and Dan Theodorescu},
  journal={Cancer research},
  year={2006},
  volume={66 4},
  pages={1917-22}
}
Ral GTPases are important mediators of transformation, tumorigenesis, and cancer progression. We recently identified the metastasis-associated protein CD24, a glycosyl phosphatidyl inositol-linked surface protein, as a downstream target of Ral signaling by profiling the expression of RalA/B-depleted bladder carcinoma cells. Because CD24 is highly expressed in bladder and many other tumor types, we sought to determine if this protein plays an essential role in maintaining the malignant phenotype… CONTINUE READING
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