The metal binding site of the hepatitis C virus NS3 protease. A spectroscopic investigation.

@article{Urbani1998TheMB,
  title={The metal binding site of the hepatitis C virus NS3 protease. A spectroscopic investigation.},
  author={Andrea Urbani and Renzo Bazzo and Maria Chiara Nardi and Daniel O Cicero and Raffaele De Francesco and Christian Steink{\"u}hler and Gaetano Barbato},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 30},
  pages={18760-9}
}
The NS3 region of the hepatitis C virus encodes for a serine protease activity, which is necessary for the processing of the nonstructural region of the viral polyprotein. The minimal domain with proteolytic activity resides in the N terminus, where a structural tetradentate zinc binding site is located. The ligands being been identified by x-ray crystallography as being three cysteines (Cys97, Cys99, and Cys145) and one histidine residue (His149), which is postulated to coordinate the metal… CONTINUE READING

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