The metabotropic glutamate receptor subtype 5 antagonist fenobam is analgesic and has improved in vivo selectivity compared with the prototypical antagonist 2-methyl-6-(phenylethynyl)-pyridine.

@article{Montana2009TheMG,
  title={The metabotropic glutamate receptor subtype 5 antagonist fenobam is analgesic and has improved in vivo selectivity compared with the prototypical antagonist 2-methyl-6-(phenylethynyl)-pyridine.},
  author={Michael C. Montana and Laura F Cavallone and Kristi K Stubbert and Andrei Stefanescu and Evan D. Kharasch and Robert W Gereau},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2009},
  volume={330 3},
  pages={834-43}
}
Metabotropic glutamate receptor subtype 5 (mGlu5) has been demonstrated to play a role in the modulation of numerous nociceptive modalities. When administered via peripheral, intrathecal, or systemic routes, mGlu5 antagonists have analgesic properties in a variety of preclinical pain models. Despite a wealth of data supporting the use of mGlu5 antagonists to treat pain, studies have been limited to preclinical animal models due to a lack of mGlu5 antagonists that are approved for use in humans… CONTINUE READING

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Peripheral group I

  • G Bhave, F Karim, SM Carlton, RW Gereau
  • 2001
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