The metabotropic glutamate G-protein-coupled receptors mGluR3 and mGluR1a are voltage-sensitive.

@article{Ohana2006TheMG,
  title={The metabotropic glutamate G-protein-coupled receptors mGluR3 and mGluR1a are voltage-sensitive.},
  author={Lily Ohana and Ofra Barchad and Itzchak Parnas and Hanna Parnas},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 34},
  pages={24204-15}
}
G-protein-coupled receptors play a key role in signal transduction processes. Despite G-protein-coupled receptors being transmembrane proteins, the notion that they exhibit voltage sensitivity is rather novel. Here we examine whether two metabotropic glutamate receptors, mGluR3 and mGluR1a, both involved in fundamental physiological processes, exhibit, by themselves, voltage sensitivity. Measuring mGluR3-induced K(+) currents and mGluR1a-induced Ca(2+)-activated Cl(-) currents in Xenopus… CONTINUE READING

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