The metabotropic glutamate 2/3 receptor agonist LY379268 counteracted ketamine-and apomorphine-induced performance deficits in the object recognition task, but not object location task, in rats.

Abstract

Experimental evidence indicates that the non competitive N-methyl-d-aspartate (NMDA) receptor antagonist ketamine and the mixed dopamine (DA) D1/D2 receptor agonist apomorphine induce schizophrenia-like symptoms in rodents, including cognitive deficits. Activation of Group II metabotropic glutamate 2/3 (mGlu2/3) receptors reduces the excessive glutamate… (More)
DOI: 10.1016/j.neuropharm.2014.05.008

Topics

Cite this paper

@article{Pitsikas2014TheMG, title={The metabotropic glutamate 2/3 receptor agonist LY379268 counteracted ketamine-and apomorphine-induced performance deficits in the object recognition task, but not object location task, in rats.}, author={Nikolaos Pitsikas and Athina Markou}, journal={Neuropharmacology}, year={2014}, volume={85}, pages={27-35} }