The metabotropic GABAB receptor directly interacts with the activating transcription factor 4.

@article{Nehring2000TheMG,
  title={The metabotropic GABAB receptor directly interacts with the activating transcription factor 4.},
  author={Ralf B. Nehring and Hiroshi P M Horikawa and Oussama El Far and Matthias Kneussel and Johann Helmut Brandst{\"a}tter and Stefan Stamm and Erhard Wischmeyer and Heinrich Betz and Andreas Karschin},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 45},
  pages={35185-91}
}
G protein-coupled receptors regulate gene expression by cellular signaling cascades that target transcription factors and their recognition by specific DNA sequences. In the central nervous system, heteromeric metabotropic gamma-aminobutyric acid type B (GABA(B)) receptors through adenylyl cyclase regulate cAMP levels, which may control transcription factor binding to the cAMP response element. Using yeast-two hybrid screens of rat brain libraries, we now demonstrate that GABA(B) receptors are… CONTINUE READING

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