The metabolism or atropine in man

@article{Meer1986TheMO,
  title={The metabolism or atropine in man},
  author={M. J. Meer and Hans K. L. Hundt and F. Otto M{\"u}ller},
  journal={Journal of Pharmacy and Pharmacology},
  year={1986},
  volume={38}
}
A metabolic pattern of atropine in man, based on the detection of radiolabelled products in urine by high performance liquid chromatography after administration of [3H]atropine sulphate to a normal volunteer is proposed. Noratropine (24%), atropine‐N‐oxide (equatorial isomer) (15%), tropine (2%) and tropic acid (3%) appear to be the major metabolites, while 50% of the administered dose is excreted as apparently unchanged atropine. No conjugates were detectable. Evidence that atropine is present… 
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18 Citations
Background Citations
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18 Citations

Atropine pharmacokinetics are affected by moderate hemorrhage and hypothyroidism
TLDR
Results suggest that atropine kinetics are not altered appreciably during moderate hemorrhage, and in hypothyroidism, alterations inAtropine pharmacokinetics may warrant modification of drug dose and frequency of administration.
How to Induce Arrhythmias with Atropine
Atropine sulfate is the sulfate salt of atropine, which is an alkaloid found in its natural form together with scopolamine and hyoscyamine in the plant Atropa belladonna. The first synthesis of…
Application of an enantioselective LC-ESI MS/MS procedure to determine R- and S-hyoscyamine following intravenous atropine administration in swine.
TLDR
Similar kinetics for both enantiomers were revealed thus indicating distribution, metabolism and elimination without obvious stereoselective preference in tested swine, thus indicating treatment of OP poisoning can be optimized.
Plasma level of atropine after accidental ingestion of Atropa belladonna
TLDR
Plasma levels of atropine may be useful in confirming the cause of intoxication and elucidate mechanisms in this type of exposure, and receptor binding may help confirm diagnosis and elucidates mechanisms.
LC–MS for Identification and Elucidation of the Structure of In-Vivo and In-Vitro Metabolites of Atropine
TLDR
In-vivo and in-vitro metabolism of atropine has been investigated by use of a highly specific and sensitive LC–MSn method and ten new metabolites were identified in rat urine after ingestion of atypine.
Plasma and urine concentrations of atropine after the ingestion of cooked deadly nightshade berries.
TLDR
Four children and one adult exhibited mild peripheral anticholinergic symptoms and one patient fell into a coma and required mechanical ventilation after accidental ingestion of ripened Atropa belladonna berries.
The Metabolism and Biochemical Actions of Alkaloids in Animals
The Role of Atropine in Preventing Myopia Progression: An Update
TLDR
The pharmacokinetic, pharmacodynamic, clinical, and tolerability profile revealed first by the multicenter, randomized ATOM 1 and 2 trials and, more recently, by the LAMP Study confirmed the efficacy of low-concentration atropine with a concentration-dependent response.
Kinetic and polarographic study on atropine N-oxide: its obtaining and polarographic reduction
The work presents the obtaining of atropine N-oxide using various peroxyacids (organic monoperoxyacid, diperoxyacids and inorganic peroxyacids). The kinetics of atropine oxidation with various…
Scientific Opinion on Tropane alkaloids in food and feed
TLDR
Estimates of exposure for livestock based on example diets and levels of EAs in cereal grains reported suggest that under normal conditions the risk of toxicosis is low and the Panel concluded that whilst the available data do not indicate a concern for any population subgroup, the dietary exposure estimates relate to a limited number of food groups and a possible unknown contribution from other foods cannot be discounted.
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