The metabolism of the erythrocyte. IX. Diphosphopyridine nucleotidase of erythrocytes.

@article{Alivisatos1956TheMO,
  title={The metabolism of the erythrocyte. IX. Diphosphopyridine nucleotidase of erythrocytes.},
  author={Spyridon G.A. Alivisatos and Shelby Kashket and Orville F. Denstedt},
  journal={Canadian journal of biochemistry and physiology},
  year={1956},
  volume={34 1},
  pages={
          46-60
        }
}
The rabbit erythrocyte possesses an active DPN-ase which is firmly attached to the membrane of the cell. Evidently, the enzyme is oriented in the membrane in such a way as to be able to act upon DPN added to the external medium. The enzyme splits DPN at the bond linking the quaternary nitrogen of the nicotinamide moiety with the ribose component. Despite the release of an H+ ion during hydrolysis of DPN, the activity of the enzyme remains practically constant over the pH range from 4.5 to 10.0… 
The Role of Membrane Phosphoglycerate Kinase in the Control of Glycolytic Rate by Active Cation Transport in Human Red Blood Cells
When the internal Na of human red cells is raised, both K influx and lactate production increase and become more sensitive to the inhibitory action of ouabain. This occurs with either glucose or
Some enzymologic aspects of the human erythrocyte.
  • K. Altman
  • Biology
    The American journal of medicine
  • 1959
Die Aktivität der DPN- und TPN-Nucleosidase des Gehirns nach Einwirkung verschiedener Pharmaka
  • H. Coper
  • Chemistry, Biology
    Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie
  • 2004
TLDR
The drugs INH and Iproniazid are also inhibitors of nucleosidase, whereas other derivates of nicotinamide for example 3-Acetylpyridine and Pyridinecarbonic acid-diethylamid (Nicethamide) are ineffective.
The inhibitory effect of xanthine derivatives on alkaline phosphatase in the rat brain
TLDR
Histochemical and biochemical studies were carried out on the inhibition of alkaline phosphatase (Al-P) activity in rat cerebral cortex with various methylxanthine derivatives, and the biological role of Al-P in the central nervous system was discussed.
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References

Breakdown of cozymase by a system from nervous tissue.
TLDR
It is apparent that the nucleus must have a very low metabolism indeed and this fact, coupled with the disappearance of the cell nuclei from these central cells, would support the view of an increased permeability to sodium.