The metabolism of oestrone and some other steroids in isolated perfused rat and guinea pig livers.

@article{Roy1987TheMO,
  title={The metabolism of oestrone and some other steroids in isolated perfused rat and guinea pig livers.},
  author={Aniket Basu Roy and C. Gerald Curtis and Gillian M. Powell},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={1987},
  volume={17 11},
  pages={1299-313}
}
1. Oestrone is rapidly taken up by isolated perfused rat liver (t 1/2 less than 2 min) to yield at least 10 metabolites excreted in the bile; peak concentration occurs after about 20 min. 2. Sulphated metabolites of oestrone appear in the perfusate, reaching peak concentration at about 10 min, and then slowly disappear. 3. Sulphated metabolites of oestrone… CONTINUE READING