The metabolism of intense sweeteners.

@article{Renwick1986TheMO,
  title={The metabolism of intense sweeteners.},
  author={Alistair G.C. Renwick},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={1986},
  volume={16 10-11},
  pages={
          1057-71
        }
}
Three organic acids (saccharin, acesulfame-K and cyclamate) are used or have been used extensively as intense sweeteners. Once absorbed from the gut they are eliminated, largely in the urine, without undergoing metabolism. Early studies using radiolabelled saccharin indicated the existence of limited metabolism, but this was not confirmed by later more extensive studies using highly purified compound. Metabolism could not be induced by a variety of pretreatments. Following an initial report of… CONTINUE READING
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