The metabolism of human mesenchymal stem cells during proliferation and differentiation

@article{Pattappa2011TheMO,
  title={The metabolism of human mesenchymal stem cells during proliferation and differentiation},
  author={G. Pattappa and H. Heywood and J. D. de Bruijn and David A Lee},
  journal={Journal of Cellular Physiology},
  year={2011},
  volume={226}
}
Human mesenchymal stem cells (MSCs) reside under hypoxic conditions in vivo, between 4% and 7% oxygen. Differentiation of MSCs under hypoxic conditions results in inhibited osteogenesis, while chondrogenesis is unaffected. The reasons for these results may be associated with the inherent metabolism of the cells. The present investigation measured the oxygen consumption, glucose consumption and lactate production of MSCs during proliferation and subsequent differentiation towards the osteogenic… Expand
Energy Metabolism in Mesenchymal Stem Cells During Osteogenic Differentiation.
Oxygenated environment enhances both stem cell survival and osteogenic differentiation.
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