The metabolism of homocysteine: pathways and regulation

@article{Finkelstein1998TheMO,
  title={The metabolism of homocysteine: pathways and regulation},
  author={James D. Finkelstein},
  journal={European Journal of Pediatrics},
  year={1998},
  volume={157},
  pages={S40-S44}
}
  • J. Finkelstein
  • Published 24 March 1998
  • Biology, Medicine
  • European Journal of Pediatrics
Abstract Two pathways, the methionine cycle and transsulfuration, account for virtually all methionine metabolism in mammals. Every tissue possesses the methionine cycle. Therefore, each can synthesize AdoMet, employ it for transmethylation, hydrolyze AdoHcy, and remethylate homocysteine. Transsulfuration, which occurs only in liver, kidney, small intestine and pancreas, is the means for catabolizing homocysteine. Liver has a unique isoenzyme of MAT that allows the utilization of excess… 
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TLDR
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TLDR
Hyperhomocysteinaemia has been regarded as a new modifiable risk factor for atherosclerosis and vascular disease and a link has been postulated between homocysteine, or its intermediates, and an alterated DNA methylation pattern.
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TLDR
The advantages of yeast as an experimental system to understand pathologies associated with AdoHcy accumulation will be discussed and the strong product inhibitor S-adenosyl-L-homocysteine hydrolase is discussed.
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TLDR
Results show that insulin has a direct role in regulating homocysteine metabolism by regulating the hepatic transsulfuration pathway.
Effects of moderate hyperhomocysteinaemia induced by 4 weeks methionine-enriched diet on metabolite profile and mesenteric artery function in rats
TLDR
A 2-fold elevation of plasma homocysteine did not impair mesenteric artery vasodilatation during 4 weeks of a methionine-rich diet, and asymmetrical dimethylarginine and adenosine, which have been shown to be changed in more severe degrees of hyperhomocysteinaemia, remained unaltered.
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TLDR
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TLDR
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TLDR
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TLDR
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  • Chemistry, Medicine
    The Journal of nutritional biochemistry
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TLDR
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TLDR
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