The metabolism of dihomo-γ-linolenic acid in man

  title={The metabolism of dihomo-$\gamma$-linolenic acid in man},
  author={Keith Joseph Stone and Anthony L. Willis and M. Hart and Stephen J. Kirtland and Peter B. A. Kernoff and G. P. Mcnicol},
Orally adminstered dihomo-γ-linolenic acid (DHLA) is well absorbed in man; it appears in blood after ca. 4 hr first as triglyceride ester and later as phospholipid. After sustained-dosing, DHLA penetrated membrane pools and all phospholipid components but, depending on the dosage, reached a metabolic equilibrium in 4–16 days. Intact plateles do not accumulate arachidonate following DHLA administration, and species differences occur in the capacity of animals to metabolize DHLA to arachidonic… Expand

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