The metabolism of dihomo-γ-linolenic acid in man

@article{Stone2006TheMO,
  title={The metabolism of dihomo-$\gamma$-linolenic acid in man},
  author={Keith Joseph Stone and Anthony L. Willis and M. Hart and Stephen J. Kirtland and Peter B. A. Kernoff and G. P. Mcnicol},
  journal={Lipids},
  year={2006},
  volume={14},
  pages={174-180}
}
Orally adminstered dihomo-γ-linolenic acid (DHLA) is well absorbed in man; it appears in blood after ca. 4 hr first as triglyceride ester and later as phospholipid. After sustained-dosing, DHLA penetrated membrane pools and all phospholipid components but, depending on the dosage, reached a metabolic equilibrium in 4–16 days. Intact plateles do not accumulate arachidonate following DHLA administration, and species differences occur in the capacity of animals to metabolize DHLA to arachidonic… Expand

Figures and Tables from this paper

Influence of Dietary Arachidonic Acid on Metabolism
This study investigated the influence of dietary arachidonic acid (20:4n-6) on Ll5 desaturation and incorporation of deuterium-labeled 8cis, 11 cis, 14-eicosatrienoic acid (20:3n-6) into human plasmaExpand
Enteral absorption in man of eicosapentaenoic acid in different chemical forms
TLDR
The results and the data in the literature are compatible with the hypothesis that 2-EPA is absorbed with minimum hydrolysis and escapes random distribution between the other positions of the glycerol molecule during the absorption process. Expand
Age-related changes in Δ6 and Δ5 desaturase activities in rat liver microsomes
TLDR
The results suggest that, in liver, the activity of desaturases may be regulated in the course of aging to maintain a constant level of polyunsaturated fatty acids in cellular membranes. Expand
Borage or primrose oil added to standardized diets are equivalent sources for γ-linolenic acid in rats
TLDR
The amount of dietary GLA administered did not significantly influence prostaglandin E2 production in stimulated aortic rings and thromboxane B2 levels in serum; however, an increase in prostaglandsin E1 derived from DHLA was observed in the supernatants of stimulated aorts, and the arachidonic acid/DHLA ratios in tissues decreased with increasing intake of dietaryGLA. Expand
Modulation of eicosanoid production and cell-mediated cytotoxicity by dietary α-linolenic acid in BALB/c mice
TLDR
Feeding mice a diet rich in 18∶3n−3 elevates immune cell n−3 fatty acid content, reduces eicosanoid synthesis and, to a limited extent, enhances the cell-mediated cytotoxic response to a viral challenge. Expand
Intravenous injection of tridihomo-γ-linolenoyl-glycerol into mice and its effects on delayed-type hypersensitivity
TLDR
Highly purified tridihomo-γ-linolenoyl-glycerol was emulsified with egg yolk lecithin as a 10% DGLA-TG emulsion and injected into mice to investigate its effects on the fatty acid composition of spleen cells and on delayed-type hypersensitivity (DTH) response. Expand
Extremely limited synthesis of long chain polyunsaturates in adults: implications for their dietary essentiality and use as supplements.
  • M. Plourde, S. Cunnane
  • Biology, Medicine
  • Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme
  • 2007
There is considerable interest in the potential impact of several polyunsaturated fatty acids (PUFAs) in mitigating the significant morbidity and mortality caused by degenerative diseases of theExpand
The effects oftrans fatty acids on fatty acyl Δ5 desaturation by human skin fibroblasts
The effectiveness of different fatty acids as inhibitors of fatty acyl Δ5 desaturation activity in human skin fibroblasts has been investigated. When incubated with 2.25 μM [14C] eicosatrienoateExpand
Heterologous Production of Dihomo-γ-Linolenic Acid in Saccharomyces cerevisiae
TLDR
To the authors' knowledge, this is the first report describing the production of polyunsaturated fatty acids in S. cerevisiae without supplying the exogenous fatty acids. Expand
Suppression of Leukotriene B4 Generation by Ex-vivo Neutrophils Isolated from Asthma Patients on Dietary Supplementation with Gammalinolenic Acid-containing Borage Oil: Possible Implication in Asthma
Dietary gammalinolenic acid (GLA), a potent inhibitor of 5-lipoxygenase (5-LOX) and suppressor of leukotriene B4 (LTB4), can attenuate the clinical course of rheumatoid arthritics, with negligibleExpand
...
1
2
3
4
...

References

SHOWING 1-10 OF 16 REFERENCES
Antithrombotic potential of dihomo-gamma-linolenic acid in man.
TLDR
DHLA seems to have considerable potential as an agent for preventing and treating human thromboembolic disease, particularly when DHLA also accumulated in red cell membranes. Expand
Effects of feeding ethyl-dihomo-gamma-linolenate on prostaglandin biosynthesis and platelet aggregation in the rabbit.
TLDR
It is concluded that prostaglandsin E biosynthesis can be increased by enriching the prostaglandin precursor pool by feeding the ethyl ester of dihomo-gamma-linolenic acid. Expand
Enrichment of rat tissue lipids with fatty acids that are prostaglandin precursors.
TLDR
The ability to modify 20 : 3Omega6 levels selectively in certain tissues is of interest in light of such pharmacologic differences from 20 : 4. Expand
The preferred metabolic pathway from linoleic acid to arachidonic acid in vitro.
TLDR
The desaturation of eicosa-8,11,14-trienoic acid is strongly enhanced by linoleic and γ-linolenic acids which may account for its non-accumulation in tissue lipids. Expand
Inability of the cat to desaturate essential fatty acids
TLDR
A wide range of naturally occurring polyunsaturated fatty acids have been shown to exhibit EFA activity, but they can be classified into two homologous series characterised by the position of the terminal double bonds relative to the methyl (omega) carbon atom. Expand
Selective release of archidonic acid from the phospholipids of human platelets in response to thrombin.
TLDR
The present studies show that human platelets contain phospholipase A2 activities that preferentially release arachidonic acid, and one of these activities specifically utilizes 1-acyl-2-arachidonyl-phosphatidyl-choline, both of which are highly enriched with arachIDonic acid. Expand
Metabolism of [14C]arachidonic acid by human platelets.
TLDR
When platelets, so labelled, were washed and treated with thrombin, there was a major decrease in the radioactivity of phosphatidylcholine and phosph atidylinositol, accounted for by the appearance of several previously identified 14C-labelled oxygenated products of arachidonic acid. Expand
An endoperoxide aggregator (Lass), formed in platelets in response to thrombotic stimuli: purification, identification and unique biological significance.
TLDR
It is concluded that platelet biosynthesis of LASS and PGE 2 mediates (in part or in full) irreversible platelet aggregation and the release reaction induced by collagen, thrombin, arachidonate, epinephrine or ADP. Expand
Malondialdehyde formation as an indicator of prostaglandin production by human platelets.
TLDR
The formation of malondialdehyde, a metabolite of prostaglandin endoperoxides, has been studied in platelet-rich plasma and was prevented by aspirin or indomethacin. Expand
Lipid composition of subcellular particles of human blood platelets.
TLDR
The phospholipid composition of platelets and subcellular fractions was found to differ only in that granules had a lower percentage of lecithin, but the basic lipid composition of the granules, membranes, and platelets was similar. Expand
...
1
2
...