The metabolism of a substituted aminoacetamido-benzophenone and cyclization to the corresponding benzodiazepine in the rat in vivo.

@article{Rising1977TheMO,
  title={The metabolism of a substituted aminoacetamido-benzophenone and cyclization to the corresponding benzodiazepine in the rat in vivo.},
  author={P A Rising and H. P. A. Illing and Per Johnson and M A Yeomans},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={1977},
  volume={7 7},
  pages={425-37}
}
1. 2-(5-Cyano-N-methyl-3,5-dimethyl-3-aza-pentanamido)-5-nitrobenzophenone, administered orally to the rat, is well absorbed and extensively metabolized with only minimal quantities of parent compound detected in plasma, bile or urine. 2. Urinary t.l.c. metabolite profiles after oral administration of a substituted aminoacetamidobenzophenone, [14C]C 72 0045, and [14C]nimetazepam were qualitatively similar but differed quantitatively. 3. Analysis by t.l.c. of plasma extracts obtained after oral… CONTINUE READING

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