The metabolism and pharmacokinetics of phospho‐sulindac (OXT‐328) and the effect of difluoromethylornithine

@article{Xie2012TheMA,
  title={The metabolism and pharmacokinetics of phospho‐sulindac (OXT‐328) and the effect of difluoromethylornithine},
  author={G. Xie and T. Nie and G. Mackenzie and Y. Sun and L. Huang and N. Ouyang and N. Alston and C. Zhu and O. T. Murray and P. Constantinides and L. Kopelovich and B. Rigas},
  journal={British Journal of Pharmacology},
  year={2012},
  volume={165}
}
BACKGROUND AND PURPOSE Phospho‐sulindac (PS; OXT‐328) prevents colon cancer in mice, especially when combined with difluoromethylornithine (DFMO). Here, we explored its metabolism and pharmacokinetics. 
The in vitro metabolism of phospho-sulindac amide, a novel potential anticancer agent.
Topical phospho-sulindac (OXT-328) is effective in the treatment of non-melanoma skin cancer
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