The metabolism and fate of tritiated thymidine in man.

@article{Rubini1960TheMA,
  title={The metabolism and fate of tritiated thymidine in man.},
  author={J R Rubini and Eugene P. Cronkite and Victor P Bond and Theodor M. Fliedner},
  journal={The Journal of clinical investigation},
  year={1960},
  volume={39},
  pages={909-18}
}
The incorporation of thymidine (thymine deoxyriboside) into deoxyribonucleic acid (DNA) of proliferating cells has been studied in the past with various isotopic labels and biochemical techniques. Reichard and Estborn showed that thymidine-N15 was a specific precursor of DNAthymine in rats (1). Friedkin, Tilson, Roberts and Wood (2, 3) used thymidine-2-CI4 to show that this compound was incorporated into DNAthymidine of proliferating embryo and animal tissues with negligible partition of… CONTINUE READING

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