The metabolism and fate of closantel (Flukiver) in sheep and cattle.

Abstract

Closantel was reasonably well absorbed in sheep and cattle. After oral (10 mg/kg) or parenteral (5 mg/kg) administration, similar peak times (8-48 h) and peak plasma levels (45-55 micrograms/mL) are observed. Plasma level-time curves are superimposable for either route and increase linearly with the dose. The elimination half-life of closantel is 2 to 3… (More)

Topics

Cite this paper

@article{Michiels1987TheMA, title={The metabolism and fate of closantel (Flukiver) in sheep and cattle.}, author={Maria Michiels and Willem E. G. Meuldermans and Joseph Heykants}, journal={Drug metabolism reviews}, year={1987}, volume={18 2-3}, pages={235-51} }