The metabolism and excretion of prochloraz, an imidazole-based fungicide, in the rat.

@article{Needham1991TheMA,
  title={The metabolism and excretion of prochloraz, an imidazole-based fungicide, in the rat.},
  author={Dale Needham and I R Challis},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={1991},
  volume={21 11},
  pages={1473-82}
}
1. Following oral administration of prochloraz (1-[N-propyl-N-2-(2,4,6-trichlorophenoxy)ethylcarbamoyl]imidazole) at 100 mg/kg body weight to rats, the compound underwent extensive metabolism, the primary route appearing to be opening of the imidazole ring followed by hydrolysis of the alkyl chain. The major metabolites were 2,4,6-trichlorophenoxyacetic acid and 2-(2,4,6-trichlorophenoxy)ethanol, which is present mainly as a glucuronide conjugate. Ring hydroxylation occurred to produce several… CONTINUE READING

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