The metabolism and excretion of buprenorphine in humans.

  title={The metabolism and excretion of buprenorphine in humans.},
  author={Edward J. Cone and Charles W. Gorodetzky and D Yousefnejad and W. F. Buchwald and Ruth E. Johnson},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  volume={12 5},
Buprenorphine, a powerful mixed agonist-antagonist analgesic which shows promise of providing maintenance pharmacotherapy for heroin addicts, is metabolized in male human subjects to norbuprenorphine and to conjugated buprenorphine and norbuprenorphine. Following subcutaneous, sublingual, and oral buprenorphine administration to a single subject, total metabolite excretion in urine was 2, 13.4, and 12.1%, respectively. No free parent drug was detected in urine. The amount of norbuprenorphine… CONTINUE READING


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