The metabolic topography of normal aging.

  title={The metabolic topography of normal aging.},
  author={James R. Moeller and Tatsuya Ishikawa and Vijay Dhawan and Phoebe G. Spetsieris and Francine Mandel and Gene E. Alexander and Cheryl Grady and Pietro Pietrini and David Eidelberg},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  volume={16 3},
Normal aging is associated with the degeneration of specific neural systems. We used [18F] fluorodeoxyglucose (FDG)/positron emission tomography (PET) and a statistical model of regional covariation to explore the metabolic topography of this process. We calculated global and regional metabolic rates for glucose (GMR and rCMRglc) in two groups of normal subjects studied independently on different tomographs: Group 1--130 normal subjects (62 men and 68 women; range 21-90 years); Group 2--20… CONTINUE READING
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