The metabolic switch and its regulation in cancer cells

  title={The metabolic switch and its regulation in cancer cells},
  author={Shengtao Zhou and Canhua Huang and Yu-Quan Wei},
  journal={Science China Life Sciences},
The primary features of cancer are maintained via intrinsically modified metabolic activity, which is characterized by enhanced nutrient supply, energy production, and biosynthetic activity to synthesize a variety of macromolecular components during each passage through the cell cycle. This metabolic shift in transformed cells, as compared with non-proliferating cells, involves aberrant activation of aerobic glycolysis, de novo lipid biosynthesis and glutamine-dependent anaplerosis to fuel… CONTINUE READING

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