The metabolic sensors FXRα, PGC‐1 α, and SIRT1 cooperatively regulate hepatitis B virus transcription

  title={The metabolic sensors FXR$\alpha$, PGC‐1 $\alpha$, and SIRT1 cooperatively regulate hepatitis B virus transcription},
  author={Claire Curtil and Liviu Sorin Enache and Pauline Radreau and Anne-Ga{\"e}lle Dron and Caroline Scholt{\`e}s and A. Deloire and Didier Roche and Vincent Lotteau and Patrice Andr{\'e} and Christophe Rami{\`e}re},
  journal={The FASEB Journal},
  pages={1454 - 1463}
Hepatitis B virus (HBV) genome transcription is highly dependent on liver‐enriched, metabolic nuclear receptors (NRs). Among others, NR farnesoid X receptor a (FXRa) enhances HBV core promoter activity and pregenomic RNA synthesis. Interestingly, two food‐withdrawal‐induced FXRα modulators, peroxisome proliferator‐activated receptor‐γ coactivator 1α (PGC‐1α) and deacetylase SIRT1, have been found to be associated with HBV genomes ex vivo. Whereas PGC‐1α induction was shown to increase HBV… 

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