The metabolic role of leucovorin.


Interest in determining if leucovorin, known chemically as 5-formyltetra-hydrofolate, plays a role in one-carbon metabolism is reemerging. While investigations in the 1940s suggested it was an important donor of one-carbon units in folate-mediated biosynthetic reactions, studies between the 1950s and 1980s disproved this hypothesis and dismissed its… (More)


Cite this paper

@article{Stover1993TheMR, title={The metabolic role of leucovorin.}, author={Patrick J Stover and Verne Schirch}, journal={Trends in biochemical sciences}, year={1993}, volume={18 3}, pages={102-6} }