The metabolic role of isoleucine in detoxification of ammonia in cultured mouse neurons and astrocytes.

@article{Johansen2007TheMR,
  title={The metabolic role of isoleucine in detoxification of ammonia in cultured mouse neurons and astrocytes.},
  author={Maja L Johansen and Lasse K Bak and Arne Schousboe and Peter Iversen and Michael W J S\orensen and Susanne Keiding and Hendrik Vilstrup and Albert Gjedde and Peter Ott and Helle S\onderby Waagepetersen},
  journal={Neurochemistry international},
  year={2007},
  volume={50 7-8},
  pages={1042-51}
}
Cerebral hyperammonemia is a hallmark of hepatic encephalopathy, a debilitating condition arising secondary to liver disease. Pyruvate oxidation including tricarboxylic acid (TCA) cycle metabolism has been suggested to be inhibited by hyperammonemia at the pyruvate and alpha-ketoglutarate dehydrogenase steps. Catabolism of the branched-chain amino acid isoleucine provides both acetyl-CoA and succinyl-CoA, thus by-passing both the pyruvate dehydrogenase and the alpha-ketoglutarate dehydrogenase… CONTINUE READING

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