The metabolic regulation of sporulation and parasporal crystal formation in Bacillus thuringiensis revealed by transcriptomics and proteomics.

@article{Wang2013TheMR,
  title={The metabolic regulation of sporulation and parasporal crystal formation in Bacillus thuringiensis revealed by transcriptomics and proteomics.},
  author={Jieping Wang and Han Mei and Cao Zheng and Hongliang Qian and Cui Cui and Yang Fu and Jianmei Su and Ziduo Liu and Ziniu Yu and Jin He},
  journal={Molecular & cellular proteomics : MCP},
  year={2013},
  volume={12 5},
  pages={1363-76}
}
Bacillus thuringiensis is a well-known entomopathogenic bacterium used worldwide as an environmentally compatible biopesticide. During sporulation, B. thuringiensis accumulates a large number of parasporal crystals consisting of insecticidal crystal proteins (ICPs) that can account for nearly 20-30% of the cell's dry weight. However, the metabolic regulation mechanisms of ICP synthesis remain to be elucidated. In this study, the combined efforts in transcriptomics and proteomics mainly… CONTINUE READING