The metabolic effects of short-term administration of physiological versus high doses of GH therapy in GH deficient adults.


OBJECTIVE GH treatment has demonstrated favourable effects on most features of GH deficiency in hypopituitary adults. However, most studies employed supraphysiological GH doses, resulting in deterioration in insulin sensitivity (SI). The short-term metabolic effects of physiological doses of GH therapy in GH deficient (GHD) adults are largely unknown. We… (More)


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