• Corpus ID: 101675883

The metabolic disposition of (meth~xy-~~Cl-labelled trans-anethole, estragole and ppropxlanisole in human volunteers

@inproceedings{SANGSTERt1987TheMD,
  title={The metabolic disposition of (meth~xy-~~Cl-labelled trans-anethole, estragole and ppropxlanisole in human volunteers},
  author={Susan A. SANGSTERt and John Caldwells and Andrew J. Hutt and A Anthony and Robert L. Smith},
  year={1987}
}
1. The metabolic fates of the naturally occurring food flavours trans-anethole and estragole, and their synthetic congener p-propylanisole, have been investigated in human volunteers using the [meth~xy-'~C]-labelled compounds. The doses used were close to those encountered in the diet, 1 mg, 1OOpg and 1OOpg respectively. 2. In each case, the major routes of elimination of 14C were in the urine and in the expired air as '4C02. 3. Urinary metabolites were separated by solvent extraction, t.1.c… 

References

SHOWING 1-9 OF 9 REFERENCES
Metabolism of anethole. I. Pathways of metabolism in the rat and mouse.
The metabolism of p-propylanisole in the rat and mouse and its variation with dose.
Metabolism of anethole. II. Influence of dose size on the route of metabolism of trans-anethole in the rat and mouse.
  • S. A. Sangster, J. Caldwell, R. Smith
  • Medicine, Chemistry
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 1984
Structure-activity studies of the carcinogenicities in the mouse and rat of some naturally occurring and synthetic alkenylbenzene derivatives related to safrole and estragole.
TLDR
Twenty-three naturally occurring and synthetic alkenylbenzene derivatives structurally related to the hepatocarcinogen safrole were assayed for their hepatocARCinogenicity in mice to identify benign skin tumors that could be promoted with croton oil.
Hepatocarcinogenicity of estragole (1-allyl-4-methoxybenzene) and 1'-hydroxyestragole in the mouse and mutagenicity of 1'-acetoxyestragole in bacteria.
TLDR
Estragole induced hepatocellular carcinomas by 15 months in 23 and 39% of the mice that received total doses of 4.4 and 5.2 mumoles, respectively, and lived to an age of 12 months or more, and 1'-Acetoxyallybenzene had little or no activity in either of these tests.
Structures of the DNA adducts formed in mouse liver after administration of the proximate hepatocarcinogen 1'-hydroxyestragole.
TLDR
All four adducts in the mouse liver can be accounted for by the reaction of a metabolically derived ester of 1′-hydroxyestragole with purine bases in DNA by SN1, SN2, or SN2′ mechanisms.
Encyclopedia of Common Natural Ingredients: Used in Food, Drugs, and Cosmetics
Introduction. Glossary. Natural Ingredients. General References. General Index. Chemical Index.