The metabolic demands of cancer cells are coupled to their size and protein synthesis rates

@inproceedings{Dolfi2013TheMD,
  title={The metabolic demands of cancer cells are coupled to their size and protein synthesis rates},
  author={Sonia C. Dolfi and Leo Li-Ying Chan and Jean Qiu and Philip M. Tedeschi and Joseph R. Bertino and Kim M. Hirshfield and Zolt{\'a}n N. Oltvai and Alexei Vazquez},
  booktitle={Cancer & metabolism},
  year={2013}
}
BACKGROUND Although cells require nutrients to proliferate, most nutrient exchange rates of the NCI60 panel of cancer cell lines correlate poorly with their proliferation rate. Here, we provide evidence indicating that this inconsistency is rooted in the variability of cell size. RESULTS We integrate previously reported data characterizing genome copy number variations, gene expression, protein expression and exchange fluxes with our own measurements of cell size and protein content in the… CONTINUE READING