The metabolic checkpoint kinase mTOR is essential for interleukin-15 signaling during NK cell development and activation

@inproceedings{Marais2014TheMC,
  title={The metabolic checkpoint kinase mTOR is essential for interleukin-15 signaling during NK cell development and activation},
  author={Antoine Marçais and Julien Cherfils-Vicini and Charlotte Viant and Sophie Degouve and S{\'e}bastien Viel and Aurore Fenis and Jessica Rabilloud and Katia Mayol and Armelle Tavares and Jacques Bienvenu and Yann-Ga{\"e}l Gangloff and Eric Gilson and Eric Vivier and Thierry Walzer},
  booktitle={Nature Immunology},
  year={2014}
}
Interleukin 15 (IL-15) controls both the homeostasis and the peripheral activation of natural killer (NK) cells. The molecular basis for this duality of action remains unknown. Here we found that the metabolic checkpoint kinase mTOR was activated and boosted bioenergetic metabolism after exposure of NK cells to high concentrations of IL-15, whereas low doses of IL-15 triggered only phosphorylation of the transcription factor STAT5. mTOR stimulated the growth and nutrient uptake of NK cells and… CONTINUE READING

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