The metabolic burden of creatine synthesis

  title={The metabolic burden of creatine synthesis},
  author={John T Brosnan and Robin P. da Silva and Margaret E Brosnan},
  journal={Amino Acids},
Creatine synthesis is required in adult animals to replace creatine that is spontaneously converted to creatinine and excreted in the urine. Additionally, in growing animals it is necessary to provide creatine to the expanding tissue mass. Creatine synthesis requires three amino acids: glycine, methionine and arginine, and three enzymes: l-arginine:glycine amidinotransferase (AGAT), methionine adenosyltransferase (MAT) and guanidinoacetate methyltransferase (GAMT). The entire glycine molecule… 

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