The metabolic background is a global player in Saccharomyces gene expression epistasis

  title={The metabolic background is a global player in Saccharomyces gene expression epistasis},
  author={Mohammad Tauqeer Alam and Aleksej Zelezniak and Michael M{\"u}lleder and Pavel V. Shliaha and Roland Schwarz and Floriana Capuano and Jakob Vowinckel and E. Radmaneshfar and Antje Kr{\"u}ger and Enrica Calvani and Steve Michel and Stefan T. Boerno and Stefan Christen and Kiran Raosaheb Patil and Bernd Timmermann and Kathryn S. Lilley and Markus Ralser},
  journal={Nature Microbiology},
The regulation of gene expression in response to nutrient availability is fundamental to the genotype–phenotype relationship. The metabolic–genetic make-up of the cell, as reflected in auxotrophy, is hence likely to be a determinant of gene expression. Here, we address the importance of the metabolic–genetic background by monitoring transcriptome, proteome and metabolome in a repertoire of 16 Saccharomyces cerevisiae laboratory backgrounds, combinatorially perturbed in histidine, leucine… CONTINUE READING
16 Citations
89 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 16 extracted citations


Publications referenced by this paper.
Showing 1-10 of 89 references

The utility of protein and mRNA correlation

  • S. H. Payne
  • Trends Biochem. Sci. 40,
  • 2015

a public database of data-specific and integrated functional gene networks for Saccharomyces cerevisiae

  • Kim, H. et al. YeastNet v3
  • Nucleic Acids Res. 42, D731–D736
  • 2014

Similar Papers

Loading similar papers…