The metabolic approach to improving prognosis in ischemic heart disease

  title={The metabolic approach to improving prognosis in ischemic heart disease},
  author={Pericle Di Napoli and Villa},
Recent studies have demonstrated that alterations in cardiac metabolism can be present in ischemic heart disease and heart failure, suggesting an increased utilization of non carbohydrate substrates for energy production, with a reduction in the efficiency of myocardial oxygen consumption. A direct approach to the manipulation of cardiac energy metabolism consists in modifying substrate utilization. Trimetazidine is a pharmacological agent that shifts the preference for energy substrate away… CONTINUE READING


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