The metabolic and nutritional response to critical illness.

  title={The metabolic and nutritional response to critical illness.},
  author={Gavin G. Lavery and Paul Glover},
  journal={Current opinion in critical care},
  volume={6 4},
The metabolic response to critical illness promotes catabolism, which mobilizes substrates for energy. Initially the hypothalamic-pituitary-adrenal axis is stimulated, but later there appears to be anterior pituitary depression. Despite this, the early increase in plasma cortisol levels is usually maintained by means independent of (falling) corticotropin levels. Some patients, however, develop acute adrenal insufficiency and appear to benefit from replacement exogenous glucocorticoid. However… CONTINUE READING