The mesolimbic dopamine system: The final common pathway for the reinforcing effect of drugs of abuse?

@article{Pierce2006TheMD,
  title={The mesolimbic dopamine system: The final common pathway for the reinforcing effect of drugs of abuse?},
  author={R. Christopher Pierce and Vidhya Kumaresan},
  journal={Neuroscience \& Biobehavioral Reviews},
  year={2006},
  volume={30},
  pages={215-238}
}
Alcohol Modulation of Dopamine Release
TLDR
The rationale for this study was predicated on the belief that advancement in the understanding of the brain mechanisms underlying the recreational use and abuse potential of alcohol will pave the way for more effective treatment strategies that could reverse alcohol dependence and co-dependence and save lives and resources throughout the world.
A Brain on Cannabinoids: The Role of Dopamine Release in Reward Seeking and Addiction.
TLDR
Advances in recording techniques for dopamine are allowing unprecedented examinations of these two interacting systems and elucidating the mechanisms of endocannabinoid modulation of dopamine release in reward and addiction.
A brain on cannabinoids: the role of dopamine release in reward seeking.
  • E. Oleson, J. Cheer
  • Biology, Psychology
    Cold Spring Harbor perspectives in medicine
  • 2012
TLDR
Despite general misconceptions that cannabis is unique from other drugs of abuse, cannabis exerts identical effects on the mesolimbic dopamine system, and disrupting endocannabinoid signaling decreases drug-induced increases in dopamine release in addition to dopamine concentrations evoked by conditioned stimuli during reward seeking.
Neurobiological Basis of Drug Reward and Reinforcement
TLDR
This chapter reviews the basic concepts of reward and reinforcement, with particular emphasis on positive and negative reinforcement and the differences between goal-directed and stimulus-driven “habitual” behavior.
Regulation of brain reward by the endocannabinoid system: a critical review of behavioral studies in animals.
TLDR
It is suggested that the endocannabinoid system plays a major role in modulating motivation and reward processes and, thus, could lead to the development of potential therapeutic compounds for the treatment of reward-related disorders.
Endogenous Cholinergic Neurotransmission Contributes to Behavioral Sensitization to Morphine
TLDR
The results suggest that endogenous nicotinic cholinergic neurotransmission selectively contributes to behavioral sensitization to morphine and this process may, in part, involve cholin allergic neurons within the laterodorsal tegmental nucleus.
Alcohol-, nicotine-, and cocaine-evoked release of morphine from invertebrate ganglia: model system for screening drugs of abuse.
  • Wei Zhu, K. Mantione, G. Stefano
  • Biology
    Medical science monitor : international medical journal of experimental and clinical research
  • 2006
TLDR
The stimulatory effects of ethanol, nicotine, and cocaine on cellular expression and release of endogenous morphine suggest convergent mechanisms underlying the reinforcing and addictive properties for a variety of drugs of abuse.
Dissociable roles of mGlu5 and dopamine receptors in the rewarding and sensitizing properties of morphine and cocaine
TLDR
Dopamine receptor stimulation mediates cocaine and morphine reward but not sensitization, and the role of mGlu5 receptors in reward and sensitization is drug-specific.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 358 REFERENCES
Role of serotonin in cocaine effects in mice with reduced dopamine transporter function
TLDR
Modulation of the serotonergic system in the ventral tegmental area, where the mesolimbic dopamine system originates, is a target of cocaine action, and the ultimate effect of this serotonin mechanism in animal models with sustained elevations of dopamine may be a feed-forward enhancement of dopamine levels in the nucleus accumbens.
Modulation of cocaine self-administration in the rat through D-3 dopamine receptors.
TLDR
Three dopamine receptor agonists had affinities for binding to the D-3 receptor that correlated highly with their relative potencies in decreasing cocaine self-administration in the rat at doses that were not by themselves reinforcing.
Alcohol self-administration: further examination of the role of dopamine receptors in the nucleus accumbens.
TLDR
D1-like and D2-like receptors in the N Acc interact in the regulation of ethanol self-administration in a manner similar to their interactive regulation of other behaviors, suggesting that some intermediate level of D1 activation is required to observe the D2 effect.
Nicotine activates and desensitizes midbrain dopamine neurons
TLDR
It is shown that the same concentration of nicotine achieved by smokers activates and desensitizes multiple nicotinic receptors thereby regulating the activity of mesolimbic dopamine neurons, which could mediate the rewarding aspects of tobacco use.
Intravenous self-administration of dopamine receptor agonists by rhesus monkeys.
TLDR
The results suggest that a DA receptor that is similar to the DA2 receptor is involved in the reinforcing properties of psychomotor stimulants in rhesus monkeys, and are consistent with the hypothesis that CNS DA is involvement in the reinforcement properties of Psychomotor Stimulants.
Dose-dependent effect of ethanol on extracellular dopamine in mesolimbic striatum of awake rhesus monkeys: comparison with cocaine across individuals
TLDR
Support is provided for the ability of ethanol to elevate extracellular dopamine in the mesolimbic striatum, though with a modest effect size and variability among individuals, and suggests that some common mechanism influences the effects of ethanol and cocaine on dopaminergic output despite seemingly unrelated pharmacological mechanisms of action.
Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
  • G. Di Chiara, A. Imperato
  • Biology, Psychology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1988
The effect of various drugs on the extracellular concentration of dopamine in two terminal dopaminergic areas, the nucleus accumbens septi (a limbic area) and the dorsal caudate nucleus (a
The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine
TLDR
The data demonstrate that the reinforcing effects of nicotine occur within the central nervous system, and that the mesolimbic dopamine projection plays an important role in these effects.
...
1
2
3
4
5
...