The mesolimbic dopamine system: The final common pathway for the reinforcing effect of drugs of abuse?
@article{Pierce2006TheMD, title={The mesolimbic dopamine system: The final common pathway for the reinforcing effect of drugs of abuse?}, author={R. Christopher Pierce and Vidhya Kumaresan}, journal={Neuroscience \& Biobehavioral Reviews}, year={2006}, volume={30}, pages={215-238} }
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References
SHOWING 1-10 OF 358 REFERENCES
Role of serotonin in cocaine effects in mice with reduced dopamine transporter function
- Psychology, BiologyProceedings of the National Academy of Sciences of the United States of America
- 2003
Modulation of the serotonergic system in the ventral tegmental area, where the mesolimbic dopamine system originates, is a target of cocaine action, and the ultimate effect of this serotonin mechanism in animal models with sustained elevations of dopamine may be a feed-forward enhancement of dopamine levels in the nucleus accumbens.
Modulation of cocaine self-administration in the rat through D-3 dopamine receptors.
- Biology, PsychologyScience
- 1993
Three dopamine receptor agonists had affinities for binding to the D-3 receptor that correlated highly with their relative potencies in decreasing cocaine self-administration in the rat at doses that were not by themselves reinforcing.
Elimination of cocaine-induced hyperactivity and dopamine-mediated neurophysiological effects in dopamine D1 receptor mutant mice
- Biology, PsychologyCell
- 1994
Alcohol self-administration: further examination of the role of dopamine receptors in the nucleus accumbens.
- Biology, PsychologyAlcoholism, clinical and experimental research
- 1997
D1-like and D2-like receptors in the N Acc interact in the regulation of ethanol self-administration in a manner similar to their interactive regulation of other behaviors, suggesting that some intermediate level of D1 activation is required to observe the D2 effect.
Nicotine activates and desensitizes midbrain dopamine neurons
- Biology, PsychologyNature
- 1997
It is shown that the same concentration of nicotine achieved by smokers activates and desensitizes multiple nicotinic receptors thereby regulating the activity of mesolimbic dopamine neurons, which could mediate the rewarding aspects of tobacco use.
Intravenous self-administration of dopamine receptor agonists by rhesus monkeys.
- Biology, PsychologyThe Journal of pharmacology and experimental therapeutics
- 1984
The results suggest that a DA receptor that is similar to the DA2 receptor is involved in the reinforcing properties of psychomotor stimulants in rhesus monkeys, and are consistent with the hypothesis that CNS DA is involvement in the reinforcement properties of Psychomotor Stimulants.
Dose-dependent effect of ethanol on extracellular dopamine in mesolimbic striatum of awake rhesus monkeys: comparison with cocaine across individuals
- Psychology, BiologyPsychopharmacology
- 2002
Support is provided for the ability of ethanol to elevate extracellular dopamine in the mesolimbic striatum, though with a modest effect size and variability among individuals, and suggests that some common mechanism influences the effects of ethanol and cocaine on dopaminergic output despite seemingly unrelated pharmacological mechanisms of action.
Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
- Biology, PsychologyProceedings of the National Academy of Sciences of the United States of America
- 1988
The effect of various drugs on the extracellular concentration of dopamine in two terminal dopaminergic areas, the nucleus accumbens septi (a limbic area) and the dorsal caudate nucleus (a…
The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine
- Psychology, BiologyPsychopharmacology
- 2005
The data demonstrate that the reinforcing effects of nicotine occur within the central nervous system, and that the mesolimbic dopamine projection plays an important role in these effects.
The role of mesolimbic dopamine in the development and maintenance of ethanol reinforcement.
- Biology, PsychologyPharmacology & therapeutics
- 2004