The mesolimbic dopamine reward circuit in depression.

  title={The mesolimbic dopamine reward circuit in depression.},
  author={Eric J Nestler and William A Carlezon},
  journal={Biological psychiatry},
  volume={59 12},
The neural circuitry that mediates mood under normal and abnormal conditions remains incompletely understood. Most attention in the field has focused on hippocampal and frontal cortical regions for their role in depression and antidepressant action. While these regions no doubt play important roles in these phenomena, there is compelling evidence that other brain regions are also involved. Here we focus on the potential role of the nucleus accumbens (NAc; ventral striatum) and its dopaminergic… CONTINUE READING
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