The mesangium as a target for glomerulopathic light and heavy chains: pathogenic considerations in light and heavy chain-mediated glomerular damage.


Certain structurally abnormal light and heavy chains are known to be nephrotoxic and alter mesangial homeostasis producing pathological alterations. Many of the mechanisms involved in light chain-mesangial interactions have been deciphered using an in vitro model, providing a framework for understanding the sequence of events that leads to irreversible… (More)


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