The mer receptor tyrosine kinase: expression and function suggest a role in innate immunity.

@article{Behrens2003TheMR,
  title={The mer receptor tyrosine kinase: expression and function suggest a role in innate immunity.},
  author={Edward M Behrens and Paul Gadue and Shun-you Gong and Stacey Garrett and Paul L. Stein and Philip L. Cohen},
  journal={European journal of immunology},
  year={2003},
  volume={33 8},
  pages={2160-7}
}
The mer receptor tyrosine kinase mediates phagocytosis of apoptotic cells and modulates cytokine production; it is also required for prevention of systemic autoimmune disease. Using a mer-specific antibody, we have confirmed the presence of mer on macrophages and now report its expression on NK cells, NKT cells, and dendritic cells (DC). We found that DC do not require mer for ingestion of apoptotic cells, as DC from mer-deficient mice phagocytose apoptotic cells normally. Mer was observed in… CONTINUE READING
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