The membrane stress response buffers lethal effects of lipid disequilibrium by reprogramming the protein homeostasis network.

@article{Thibault2012TheMS,
  title={The membrane stress response buffers lethal effects of lipid disequilibrium by reprogramming the protein homeostasis network.},
  author={Guillaume Thibault and Guanghou Shui and Woong Kim and G Mcalister and Nurzian Ismail and Steven P Gygi and Markus R. Wenk and Davis T W Ng},
  journal={Molecular cell},
  year={2012},
  volume={48 1},
  pages={16-27}
}
Lipid composition can differ widely among organelles and even between leaflets of a membrane. Lipid homeostasis is critical because disequilibrium can have disease outcomes. Despite their importance, mechanisms maintaining lipid homeostasis remain poorly understood. Here, we establish a model system to study the global effects of lipid imbalance. Quantitative lipid profiling was integral to monitor changes to lipid composition and for system validation. Applying global transcriptional and… CONTINUE READING
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