The membrane-spanning segment of invariant chain (Iγ) contains a potentially cleavable signal sequence

@article{Lipp1986TheMS,
  title={The membrane-spanning segment of invariant chain (Iγ) contains a potentially cleavable signal sequence},
  author={Joachim Lipp and Bernhard Dobberstein},
  journal={Cell},
  year={1986},
  volume={46},
  pages={1103-1112}
}
The human invariant chain (I gamma) of class II histocompatibility antigens spans the membrane of the endoplasmic reticulum once. It exposes a small amino-terminal domain on the cytoplasmic side and a carboxy-terminal, glycosylated domain on the exoplasmic side of the membrane. When the exoplasmic domain of I gamma is replaced by the cytoplasmic protein chloramphenicol acetyltransferase (CAT), CAT becomes the exoplasmic, glycosylated domain of the resulting membrane protein I gamma CAT… CONTINUE READING
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Signal and membrane anchor functions overlap in the type II membrane protein I gamma CAT

The Journal of cell biology • 1988
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