The membrane-spanning domain of CD98 heavy chain promotes alpha(v)beta3 integrin signals in human extravillous trophoblasts.

@article{KabirSalmani2008TheMD,
  title={The membrane-spanning domain of CD98 heavy chain promotes alpha(v)beta3 integrin signals in human extravillous trophoblasts.},
  author={Maryam Kabir-Salmani and Michiko N. Fukuda and Masami Kanai-Azuma and Nesar U. Ahmed and Shigetatsu Shiokawa and Yoshihiro Akimoto and Keiji Fujihara Akihiro Sakai and Seishi Nagamori and Yoshikatsu Kanai and Kazuhiro Sugihara and Mitsutoshi Iwashita},
  journal={Molecular endocrinology},
  year={2008},
  volume={22 3},
  pages={707-15}
}
CD98 heavy chain (CD98hc) is expressed highly in developing human placental trophoblast. CD98hc is an amino acid transporter and is thought to function in cell fusion, adhesion, and invasion by interacting with integrins. In invasive extravillous trophoblast, alpha(v)beta(3) integrin is expressed in a temporally and spatially specific manner, which prompted us to investigate the potential role of CD98hc in signal transduction of alpha(v)beta(3) integrin. Immunocytochemistry of extravillous… CONTINUE READING

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