The membrane protein of SARS-CoV suppresses NF-kappaB activation.

@article{Fang2007TheMP,
  title={The membrane protein of SARS-CoV suppresses NF-kappaB activation.},
  author={Xiaonan Fang and Jinrong Gao and Hong Yuan Zheng and Baozong Li and Lingbao Kong and Yijuan Zhang and Wei Wang and Yingchun Zeng and Linbai Ye},
  journal={Journal of medical virology},
  year={2007},
  volume={79 10},
  pages={
          1431-9
        }
}
Severe acute respiratory syndrome coronavirus (SARS-CoV) infects many organs, such as lung, liver, and immune organs and causes life-threatening atypical pneumonia, SARS causes high morbidity and mortality rates. The molecular mechanism of SARS pathogenesis remains elusive. Inflammatory stimuli can activate IkappaB kinase (IKK) signalsome and subsequently the nuclear factor kappa B (NF-kappaB), which influences gene expression of cyclooxygenase-2 (Cox-2) along with other transcription factors… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 17 CITATIONS

The role of the IKK complex in viral infections.

VIEW 6 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Advances in Antiviral Therapies Targeting Toll-like Receptors.

  • Expert opinion on investigational drugs
  • 2016
VIEW 1 EXCERPT
CITES BACKGROUND