The membrane protein Pannexin1 forms two open-channel conformations depending on the mode of activation

@article{Wang2014TheMP,
  title={The membrane protein Pannexin1 forms two open-channel conformations depending on the mode of activation},
  author={Junjie Wang and Cinzia Ambrosi and Feng Qiu and David G. Jackson and Gina E. Sosinsky and Gerhard Dahl},
  journal={Science Signaling},
  year={2014},
  volume={7},
  pages={ra69-ra69}
}
Pannexin1 (Panx1) participates in several signaling events that involve adenosine triphosphate (ATP) release, including the innate immune response, ciliary beat in airway epithelia, and oxygen supply in the vasculature. The view that Panx1 forms a large ATP release channel has been challenged by the association of a low-conductance, small anion-selective channel with the presence of Panx1. We showed that Panx1 membrane channels can function in two distinct modes with different conductances and… CONTINUE READING
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