The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis

  title={The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis},
  author={Chand Khanna and Xiaolin Wan and Seuli M Bose and Ryan D Cassaday and Osarenoma U. Olomu and Arnulfo Mendoza and Choh L. Yeung and Richard Greg Gorlick and Stephen M. Hewitt and Lee J. Helman},
  journal={Nature Medicine},
Metastatic cancers, once established, are the primary cause of mortality associated with cancer. Previously, we used a genomic approach to identify metastasis-associated genes in cancer. From this genomic data, we selected ezrin for further study based on its role in physically and functionally connecting the actin cytoskeleton to the cell membrane. In a mouse model of osteosarcoma, a highly metastatic pediatric cancer, we found ezrin to be necessary for metastasis. By imaging metastatic cells… CONTINUE READING
Highly Influential
This paper has highly influenced 22 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Highly Cited
This paper has 322 citations. REVIEW CITATIONS
Related Discussions
This paper has been referenced on Twitter 2 times. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 196 extracted citations

Beta4 integrin promotes osteosarcoma metastasis and interacts with ezrin

Oncogene • 2009
View 5 Excerpts
Method Support
Highly Influenced

Inhibition of SIRT2 suppresses hepatic fibrosis.

American journal of physiology. Gastrointestinal and liver physiology • 2016
View 4 Excerpts
Method Support
Highly Influenced

Osteosarcoma metastasis: prospective role of ezrin

Tumor Biology • 2014
View 10 Excerpts
Highly Influenced

323 Citations

Citations per Year
Semantic Scholar estimates that this publication has 323 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-10 of 26 references

Critical steps in hematogenous metastasis: an overview.

Surgical oncology clinics of North America • 2001