The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis

@article{Khanna2004TheML,
  title={The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis},
  author={Chand Khanna and Xiaolin Wan and Seuli M Bose and Ryan D Cassaday and Osarenoma U. Olomu and Arnulfo Mendoza and Choh L. Yeung and Richard Greg Gorlick and Stephen M. Hewitt and Lee J. Helman},
  journal={Nature Medicine},
  year={2004},
  volume={10},
  pages={182-186}
}
Metastatic cancers, once established, are the primary cause of mortality associated with cancer. Previously, we used a genomic approach to identify metastasis-associated genes in cancer. From this genomic data, we selected ezrin for further study based on its role in physically and functionally connecting the actin cytoskeleton to the cell membrane. In a mouse model of osteosarcoma, a highly metastatic pediatric cancer, we found ezrin to be necessary for metastasis. By imaging metastatic cells… CONTINUE READING
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