The membrane-bound isoform of stem cell factor synergizes with soluble flt3 ligand in supporting early hematopoietic cells in long-term cultures of normal and aplastic anemia bone marrow.

@article{Krieger1998TheMI,
  title={The membrane-bound isoform of stem cell factor synergizes with soluble flt3 ligand in supporting early hematopoietic cells in long-term cultures of normal and aplastic anemia bone marrow.},
  author={M S Slanicka Krieger and Catherine H. Nissen and C Y Manz and Deniz Toksoz and Stewart D. Lyman and Aleksandra Wodnar-Filipowicz},
  journal={Experimental hematology},
  year={1998},
  volume={26 5},
  pages={
          365-73
        }
}
The hematopoietic growth factors stem cell factor (SCF) and flt3 ligand (flt3L) are produced within the hematopoietic microenvironment in a membrane-bound and soluble isoform. To elucidate the relevance of the two isoforms in the network of early-acting cytokines, we examined the interaction of membrane-bound SCF with the soluble forms of SCF and flt3L in long-term cultures of human bone marrow cells. Feeder layers of the murine SCF-deficient Steel stromal cell line transfected with human cDNA… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 17 CITATIONS

Role of stem cell factor and its receptor in the pathogenesis of pediatric aplastic anemia

  • Journal of Huazhong University of Science and Technology [Medical Sciences]
  • 2005