The membrane-associated inhibitor of apoptosis protein, BRUCE/Apollon, antagonizes both the precursor and mature forms of Smac and caspase-9.

@article{Qiu2005TheMI,
  title={The membrane-associated inhibitor of apoptosis protein, BRUCE/Apollon, antagonizes both the precursor and mature forms of Smac and caspase-9.},
  author={X B Qiu and Alfred L Goldberg},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 1},
  pages={174-82}
}
Smac/DIABLO, HtrA2/Omi, and caspase-9 play key roles in the initiation of apoptosis. The inhibitor of apoptosis proteins (IAPs) are believed to bind to the N-terminal IAP binding motifs of the mature (proteolytically processed) forms of Smac, HtrA2, and caspase-9. However, we show here that BRUCE/Apollon, a 528-kDa IAP whose degradation promotes apoptosis, associates with their precursors as well as the mature forms by binding to regions in addition to the IAP binding motif. Through these… CONTINUE READING

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References

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BRUCE Inhibits Apoptosis by a Novel Mechanism

Z. Song, X. Yao, M. Wu
J. Biol. Chem. 278, • 2003

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