The membrane-anchored metalloproteinase regulator RECK stabilizes focal adhesions and anterior–posterior polarity in fibroblasts

@article{Morioka2009TheMM,
  title={The membrane-anchored metalloproteinase regulator RECK stabilizes focal adhesions and anterior–posterior polarity in fibroblasts},
  author={Yoko Morioka and James Monypenny and Tomoko Matsuzaki and Si Shi and David B. Alexander and Hitoshi Kitayama and Makoto Noda},
  journal={Oncogene},
  year={2009},
  volume={28},
  pages={1454-1464}
}
Accumulating evidence indicates that Reversion-inducing cysteine-rich protein with Kazal motifs (RECK), a membrane-anchored matrix metalloproteinase regulator, plays crucial roles in mammalian development and tumor suppression. Its mechanisms of action at the single cell level, however, remain largely unknown. In mouse fibroblasts, RECK is abundant around the perinuclear region, membrane ruffles and cell surface. Cells lacking Reck show decreased spreading, ambiguous anterior–posterior (AP… CONTINUE READING
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