The melting pot of the MHC II peptidome.

@article{Stern2016TheMP,
  title={The melting pot of the MHC II peptidome.},
  author={Lawrence J. Stern and Laura Santambrogio},
  journal={Current opinion in immunology},
  year={2016},
  volume={40},
  pages={
          70-7
        }
}
Recent advances in mass spectrometry technology have facilitated detailed examination of MHC-II immunopeptidomes, for example the repertoires of peptides bound to MHC-II molecules expressed in antigen presenting cells. These studies have deepened our view of MHC-II presentation. Other studies have broadened our view of pathways leading up to peptide loading. Here we review these recent studies in the context of earlier work on conventional and non-conventional MHC-II processing. The message… CONTINUE READING
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