The melatonin generating system in the rat retina and pineal gland: effect of single and repeated electroconvulsive shock (ECS).


N-Acetyltransferase (NAT), a rate-limiting enzyme in the melatonin synthesis which converts serotonin to N-acetylserotonin, shows a distinct circadian rhythm in the rat pineal gland and retina, with low activities during the light phase and peak activities during the dark phase. Hydroxyindole-O-methyltransferase (HIOMT), an enzyme which methylates N… (More)


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